Modafinil (Modavigil) 200mg

Description

Before taking

Do not take modafinil if you have ever had an allergic reaction or skin rash while taking modafinil, Provigil, or armodafinil (Nuvigil).

• angina (chest pain)
• cirrhosis or other liver problem
• kidney disease
• high blood pressure, heart disease, or history of heart attack
• a history of mental illness or psychosis
• history of alcoholism or drug addiction.
• are pregnant or intending to become pregnant
• are breastfeeding or intending to breastfeed.

Modafinil is not approved for use by anyone younger than 17 years old.

Pregnancy

Based on animal data, modafinil may harm an unborn baby. There have been no adequate studies in humans. Talk to your healthcare provider about using adequate birth control methods while taking Modafinil, if you are a woman of childbearing potential. Be aware that modafinil can make certain birth control less effective. Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment and for one month after finishing your treatment. Talk with your doctor about the best methods of birth control to use while taking modafinil.

Breastfeeding

It is not known whether modafinil passes into breast milk or if it could harm a nursing baby.

Modafinil side effects

The most common side effects of modafinil are:

• a headache
• dizziness
• feeling nervous or anxious
• back pain
• nausea
• diarrhea
• an upset stomach
• sleep problems (insomnia)
• poor appetite
• a stuffy nose.

Weight loss is not a recognized side effect of modafinil, although nausea and poor appetite are common side effects of modafinil that may lead to weight loss.

Serious side effects and warnings

You should not use modafinil if you have ever had an allergic reaction or developed a skin rash while taking modafinil, Provigil, armodafinil, or Nuvigil. Angioedema and hypersensitivity reactions (including rash, difficulty swallowing, narrowing of the airways, and hypersensitivity reactions that affect multiple organs) have been reported with medications in the same class as modafinil. Stop taking modafinil and get emergency medical help if you have signs of an allergic reaction to modafinil such as hives (an itchy skin rash), difficulty breathing, or swelling of your face, lips, tongue, or throat.

Modafinil can cause skin reactions that may be severe enough to need treatment in a hospital. Stop taking this medicine and get emergency medical help if you develop any of the following, no matter how minor it appears:

• skin rash or hives, blisters or peeling
• mouth sores, trouble swallowing
• fever, shortness of breath
• swelling in your legs
• dark urine, jaundice (yellowing of the skin or eyes)
• swelling in your face, eyes, lips, tongue, or throat.

Modafinil may impair your thinking or reaction time. Be careful if you drive or do anything that requires you to be alert. Avoid other dangerous activities until you know how this medication will affect your level of wakefulness. Modafinil may not return your level of alertness to what it was before you developed narcolepsy or OSA.

Psychiatric side effects, such as anxiety, confusion, insomnia, depression, or agitation, have been reported in people treated with modafinil. Stop using modafinil and call your doctor at once if you have:

• depression or suicidal thoughts or actions
• anxiety
• hallucinations or unusual thoughts or behavior
• aggression
• being more active or talkative than usual.

Cardiovascular side effects, including chest pain, trouble breathing, uneven heartbeats, shortness of breath, or changes on an ECG have been reported in trials with modafinil. Stop taking modafinil and call your doctor if you have chest pain, trouble breathing, or uneven heartbeats.

What to avoid

Modafinil may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid other dangerous activities until you know how modafinil will affect your level of wakefulness.

Avoid drinking alcohol while taking modafinil.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Modafinil and certain other medicines may affect each other causing possible serious side effects or affecting the way each other works. Especially tell your healthcare provider if you take:

• Medications that are substrates for CYP3A4/5 (such as contraceptives, cyclosporine, midazolam, and triazolam). These may not be as effective when taken in combination with modafinil
  • Contraceptives in particular may not be as effective while taking modafinil and for one month after discontinuing it.
• Medications that are substrates for CYP2C19 (such as phenytoin, diazepam, propranolol, omeprazole, and clomipramine) may have their effect prolonged by modafinil, leading to an increased risk of side effects or toxicity.
• Warfarin. More frequent monitoring of prothrombin times/INR should be considered whenever modafinil is coadministered with warfarin
• Monoamine oxidase (MAO) inhibitors, such as isocarboxazid, phenelzine, selegiline, and tranylcypromine. Caution should be used when concomitantly administering MAO inhibitors and modafinil.